Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an
incidence of over 20 000 cases per year in the United States alone. Large chromosomal …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …

The transcription factor STAT5 is an essential downstream mediator of many tyrosine
kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which …

Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%)
and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease …

Abstract Changes in the enzymatic activity of protein arginine methyltransferase (PRMT) 5
have been associated with cancer; however, the protein's role in acute myeloid leukemia …

Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived
and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal …

The idea that tumor initiation and progression are driven by a subset of cells endowed with
stem-like properties was first described by Rudolf Virchow in 1855.'Cancer stem cells', as …

Chronic myeloid leukemia (CML) stem cell survival is not dependent on BCR-ABL protein
kinase and treatment with ABL tyrosine kinase inhibitors cures only a minority of CML …