Regulation of Staphylococcus aureus Virulence

C Jenul, AR Horswill - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has evolved a
complex regulatory network to control virulence. One of the main functions of this …

Staphylococcus aureus aggregation and coagulation mechanisms, and their function in host–pathogen interactions

HA Crosby, J Kwiecinski, AR Horswill - Advances in applied microbiology, 2016 - Elsevier
The human commensal bacterium Staphylococcus aureus can cause a wide range of
infections ranging from skin and soft tissue infections to invasive diseases like septicemia …

New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in …

S Dubrac, IG Boneca, O Poupel… - Journal of bacteriology, 2007 - Am Soc Microbiol
ABSTRACT The highly conserved WalK/WalR (also known as YycG/YycF) two-component
system is specific to low-G+ C gram-positive bacteria. While this system is essential for cell …

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression

HA Crosby, PM Schlievert, JA Merriman, JM King… - PLoS …, 2016 - journals.plos.org
Staphylococcus aureus is a human commensal and opportunistic pathogen that causes
devastating infections in a wide range of locations within the body. One of the defining …

The Staphylococcus aureus ArlRS two‐component system regulates virulence factor expression through MgrA

HA Crosby, N Tiwari, JM Kwiecinski, Z Xu… - Molecular …, 2020 - Wiley Online Library
Summary The Gram‐positive bacterium, Staphylococcus aureus, is a versatile pathogen that
can sense and adapt to a wide variety of environments within the human host, in part …

Identification of Staphylococcus aureus Proteins Recognized by the Antibody-Mediated Immune Response to a Biofilm Infection

RA Brady, JG Leid, AK Camper… - Infection and …, 2006 - Am Soc Microbiol
Staphylococcus aureus causes persistent, recurrent infections (eg, osteomyelitis) by forming
biofilms. To survey the antibody-mediated immune response and identify those proteins that …

The Virulence Regulator Sae of Staphylococcus aureus: Promoter Activities and Response to Phagocytosis-Related Signals

T Geiger, C Goerke, M Mainiero, D Kraus… - Journal of …, 2008 - Am Soc Microbiol
The two-component system SaeRS of Staphylococcus aureus is closely involved in the
regulation of major virulence factors. However, little is known about the signals leading to …

Branching out: Alterations in bacterial physiology and virulence due to branched-chain amino acid deprivation

JC Kaiser, DE Heinrichs - MBio, 2018 - Am Soc Microbiol
The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in
bacterial physiology, with roles that range from supporting protein synthesis to signaling and …

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase

K Burnside, A Lembo, M de Los Reyes, A Iliuk… - PloS one, 2010 - journals.plos.org
Exotoxins, including the hemolysins known as the alpha (α) and beta (β) toxins, play an
important role in the pathogenesis of Staphylococcus aureus infections. A random …

Myricetin protects Galleria mellonella against Staphylococcus aureus infection and inhibits multiple virulence factors

LN Silva, GCA Da Hora, TA Soares, MS Bojer… - Scientific Reports, 2017 - nature.com
Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening
infections but for which antimicrobial resistance is liming the treatment options. We report …