TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …

Metformin is the most often prescribed drug for people with type 2 diabetes (T2D). More than
120 million patients with T2D use metformin worldwide. However, monotherapy fails to …

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

Abstract Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …

Exercise results in mechanical loading of the bone and stimulates energy expenditure in the
adipose tissue. It is therefore likely that the bone secretes factors to communicate with …

Interplay between energy-storing white adipose cells and thermogenic beige adipocytes
contributes to obesity and insulin resistance. Irrespective of specialized niche, adipocytes …

The transcription factor TCF7L2 is indispensable for intestinal tissue homeostasis where it
transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal …

Current evidence highlights the importance of the genetic component in obesity and
neurodevelopmental disorders (attention-deficit hyperactivity disorder (ADHD), autism …

Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …

The TCF7L2 protein is a key transcriptional effector of the Wnt/β‐catenin signaling pathway,
regulating gene expression. It was initially identified in cancer research and embryologic …