The biology and functional importance of MAIT cells

DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …

Mucosal-associated invariant T cells and disease

A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …

Transcriptomes and metabolism define mouse and human MAIT cell populations

S Chandra, G Ascui, T Riffelmacher, A Chawla… - Science …, 2023 - science.org
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes that respond to
microbial metabolites. We defined MAIT cell populations in different organs and …

[HTML][HTML] A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization

C Petersen, DLY Dai, RCT Boutin, H Sbihi… - Cell Reports …, 2021 - cell.com
Microbiota maturation and immune development occur in parallel with, and are implicated
in, allergic diseases, and research has begun to demonstrate the importance of prenatal …

MAIT cells and the microbiome

MF Jabeen, TSC Hinks - Frontiers in Immunology, 2023 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly
enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) …

Inner-city asthma in children

P Poowuttikul, S Saini, D Seth - Clinical reviews in allergy & immunology, 2019 - Springer
Asthma in inner-city children is often severe and difficult to control. Residence in poor and
urban areas confers increased asthma morbidity even after adjusting for ethnicity, age, and …

Chronically stimulated human MAIT cells are unexpectedly potent IL‐13 producers

J Kelly, Y Minoda, T Meredith… - … and Cell Biology, 2019 - Wiley Online Library
Mucosal‐associated invariant T (MAIT) cells are unconventional T cells that recognize
antigens derived from riboflavin biosynthesis. In addition to anti‐microbial functions, human …

T-cell responses in asthma exacerbations

N Bryant, LM Muehling - Annals of Allergy, Asthma & Immunology, 2022 - Elsevier
Objective Asthma is a chronic lung disease comprising multiple endotypes and
characterized by periodic exacerbations. A diverse array of T cells has been found to …

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Y Shimizu, Y Horigane-Konakai, Y Ishii… - Frontiers in …, 2022 - frontiersin.org
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells,
play a pivotal role in host defense through engaging the mucosal immunity. Although it has …

[HTML][HTML] Overlapping and distinct features of viral and allergen immunity in the human lung

JA Harker, CM Lloyd - Immunity, 2021 - cell.com
Immunity in the human respiratory tract is provided by a diverse range of tissue-resident
cells, including specialized epithelial and macrophage populations and a network of innate …