The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated
exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …

Common germline variants of the APOE gene are major risk modifiers of neurodegenerative
and atherosclerotic diseases,–, but their effect on cancer outcome is poorly defined. Here we …

The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher
risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer's …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Few data are available concerning the role of risk markers for Alzheimer's disease (AD) in
progression to AD dementia among subjects with mild cognitive impairment (MCI). We …

Background Apolipoprotein E is a glycoprotein best known as a mediator and regulator of
lipid transport and uptake. The APOE-ε4 allele has long been associated with increased …

Lifespan is a trait of enormous personal interest. Research into the biological basis of
human lifespan, however, is hampered by the long time to death. Using a novel approach of …

Tradeoffs centrally mediate the expression of human adaptations. We propose that tradeoffs
also influence the prevalence and forms of human maladaptation manifest in disease. By …