Increasing evidence indicates that the tumor microenvironment appears to play an
increasingly important role in cancer progression and therapeutic resistance. Several types …

In recent years, in light of the promising potentials of mesenchymal stromal/stem cells
(MSCs) for carrying therapeutic anticancer genes, a complete revisitation on old …

There are numerous investigated factors that limit brain cancer treatment efficacy such as
ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of …

Cell therapy is an emerging fields in the treatment of various diseases such as
cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool …

Monoclonal antibodies (mAbs) are an important class of therapeutic agents approved for the
therapy of many types of malignancies. However, in certain cases applications of …

Cancer is one of the main problems in public health worldwide. Despite rapid advances in
the diagnosis and treatment of cancer, the efficacy of current treatment strategies is still …

Despite the proven safety of oncolytic viruses (OV) in clinical trials for glioblastoma (GBM),
their efficacy has been hindered by suboptimal spreading within the tumor. We show that …

Conspectus Light-responsive agents offer the promise of targeted therapy, whose benefits
include (i) prolonged action at the target site,(ii) overall reduced systemic dosage,(iii) …

Mesenchymal stem cells (MSCs), as self-renewing multipotent stromal cells, have been
considered promising agents for cancer treatment. A large number of studies have …

Melanoma is a leading cause of mortality from skin cancer and has a poor prognosis.
Despite rapid advances in the treatment of this tumor type, the efficacy of current chemo …