Axon regeneration in the mammalian optic nerve
PR Williams, LI Benowitz… - Annual review of vision …, 2020 - annualreviews.org
The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …
functional defects observed after traumatic injury, in degenerative diseases such as …
Optic nerve regeneration in mammals: Regenerated or spared axons?
Intraorbital optic nerve crush in rodents is widely used as a model to study axon
regeneration in the adult mammalian central nervous system. Recent studies using …
regeneration in the adult mammalian central nervous system. Recent studies using …
AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration
The aim of the present study was to determine whether adeno-associated viral vector (AAV)
mediated transfer of ciliary neurotrophic factor (CNTF) and RhoA shRNA has additive effects …
mediated transfer of ciliary neurotrophic factor (CNTF) and RhoA shRNA has additive effects …
Engineering an in vitro retinothalamic nerve model
Understanding the retinogeniculate pathway in vitro can offer insights into its development
and potential for future therapeutic applications. This study presents a Polydimethylsiloxane …
and potential for future therapeutic applications. This study presents a Polydimethylsiloxane …
Significant changes in endogenous retinal gene expression assessed 1 year after a single intraocular injection of AAV-CNTF or AAV-BDNF
CJ LeVaillant, A Sharma, J Muhling… - … therapy Methods & …, 2016 - cell.com
Use of viral vectors to deliver therapeutic genes to the central nervous system holds promise
for the treatment of neurodegenerative diseases and neurotrauma. Adeno-associated viral …
for the treatment of neurodegenerative diseases and neurotrauma. Adeno-associated viral …
Cortical AAV‐CNTF gene therapy combined with intraspinal mesenchymal precursor cell transplantation promotes functional and morphological outcomes after spinal …
SI Hodgetts, JH Yoon, A Fogliani, EA Akinpelu… - Neural …, 2018 - Wiley Online Library
Ciliary neurotrophic factor (CNTF) promotes survival and enhances long‐distance
regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene …
regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene …
Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in rats by optical coherence tomography
YF Liu, S Huang, TK Ng, JJ Liang, Y Xu, SL Chen… - Experimental eye …, 2020 - Elsevier
Gene therapy has been proposed as a feasible strategy for RGC survival and optic nerve
regeneration. Some preclinical and clinical studies revealed intraocular inflammation after …
regeneration. Some preclinical and clinical studies revealed intraocular inflammation after …
Age-related loss of VGLUT1 excitatory, but not VGAT inhibitory, immunoreactive terminals on motor neurons in spinal cords of old sarcopenic male mice
VS Krishnan, T Shavlakadze, MD Grounds, SI Hodgetts… - Biogerontology, 2018 - Springer
Age-related changes in ventral lumbar spinal cord (L3–L5) were compared in young [3
month,(M)] and old (27 M) C57BL/6J male mice. The aged mice had previously been shown …
month,(M)] and old (27 M) C57BL/6J male mice. The aged mice had previously been shown …
Tissue engineering of the nervous system
This chapter covers the challenges and approaches associated with tissue engineering in
the peripheral and central nervous systems. The natural anatomical structure and …
the peripheral and central nervous systems. The natural anatomical structure and …
Small scale production of recombinant adeno-associated viral vectors for gene delivery to the nervous system
J Verhaagen, B Hobo, EME Ehlert, R Eggers… - Retinal Gene Therapy …, 2018 - Springer
Adeno-associated viral vectors have numerous applications in neuroscience, including the
study of gene function in health and disease, targeting of light-sensitive proteins to …
study of gene function in health and disease, targeting of light-sensitive proteins to …