Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For
40 years, Alzheimer's disease pathophysiology has focused on two culprits, amyloid-β …

Glioblastoma (GBM) is an aggressive form of cancer, comprising≈ 80% of malignant brain
tumors. However, there are no effective treatments for GBM due to its heterogeneity and the …

Positron emission tomography/computed tomography (PET/CT) has dramatically altered the
landscape of noninvasive glioma evaluation, offering complementary insights to those …

Intramedullary spinal cord glioblastoma (ISCG) is lethal due to lack of effective treatment. We
previously established a rat C6-ISCG model and the antitumor effect of F3. CD-TK, an hNSC …

The brain glymphatic system is currently being explored in the context of many neurological
disorders and diseases, including traumatic brain injury, Alzheimer's disease, and ischemic …

Background Reactive astrogliosis is a hallmark of various brain pathologies, including
neurodegenerative diseases and glioblastomas. However, the specific intermediate …

Astrocytes comprise~ 50% of all brain cells and present distinct morphological, molecular
and functional properties in different brain regions. In glioblastoma (GBM), an aggressive …

Abstract The Inhibitor of Apoptosis (IAP) proteins promote cell survival and are at the nexus
of multiple inflammatory pathways. Smac mimetic compounds (SMCs) are small molecule …