The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Breast cancer is a heterogeneous disorder with different molecular subtypes and biological
characteristics for which there are diverse therapeutic approaches and clinical outcomes …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …

BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle.
Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were …

A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …

Background: Increasing numbers of BRCA1 mutation carriers are being identified in cancer
risk evaluation programs. However, no estimates of cancer risk specific to a clinic-based …

Breast cancer–susceptibility genes BRCA1 and BRCA2 have recently been identified on the
human genome. Women who carry a mutation of one of these genes have a greatly …

BACKGROUND The age‐specific proportion of breast and ovarian cancer in the general
population that is likely to be due to a breast/ovarian cancer susceptibility gene (s) is …

Introduction of tumor markers into routine clinical practice has been poorly controlled, with
few criteria or guidelines as to how such markers should be used. We propose a Tumor …

Breast carcinoma is the most common malignancy among women in developed countries.
Because family history remains the strongest single predictor of breast cancer risk, attention …