[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Detection of COVID-19-related biomarkers by electrochemical biosensors and potential for diagnosis, prognosis, and prediction of the course of the disease in the …
As a more efficient and effective way to address disease diagnosis and intervention, cutting-
edge technologies, devices, therapeutic approaches, and practices have emerged within the …
edge technologies, devices, therapeutic approaches, and practices have emerged within the …
Targeting syndecan-1: new opportunities in cancer therapy
Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for
maintaining normal cell morphology, interacting with the extracellular and intracellular …
maintaining normal cell morphology, interacting with the extracellular and intracellular …
Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling
Z Madak-Erdogan, S Band, YC Zhao, BP Smith… - Cancer research, 2019 - AACR
Obesity is a risk factor for postmenopausal estrogen receptor alpha (ERα)-positive (ER+)
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this …
breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this …
Heparanase-enhanced shedding of syndecan-1 and its role in driving disease pathogenesis and progression
Both heparanase and syndecan-1 are known to be present and active in disease
pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it …
pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it …
Syndecan-1 facilitates breast cancer metastasis to the brain
MR Sayyad, M Puchalapalli, NG Vergara… - Breast Cancer Research …, 2019 - Springer
Purpose Although survival rates for patients with localized breast cancer have increased,
patients with metastatic breast cancer still have poor prognosis. Understanding key factors …
patients with metastatic breast cancer still have poor prognosis. Understanding key factors …
Endothelial glycocalyx as biomarker for cardiovascular diseases: mechanistic and clinical implications
Introduction The endothelial surface layer is covered with abundant proteoglycans, of which
syndecans and glycosaminoglycans are major constituents. Recent Findings Among the …
syndecans and glycosaminoglycans are major constituents. Recent Findings Among the …
Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
PF Zhang, ZY Wu, WB Zhang, YQ He, K Chen… - Nature …, 2023 - nature.com
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …
VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro …
Therapeutically targeting CD138, a define multiple myeloma (MM) antigen, is not yet
approved for patients. We here developed and determined the preclinical efficacy of VIS832 …
approved for patients. We here developed and determined the preclinical efficacy of VIS832 …
Circulating heparan sulfate proteoglycans as biomarkers in health and disease
Cell-surface heparan sulfate proteoglycans (HSPGs) play key roles in regulating cell
behavior, cell signaling, and cell matrix interactions in both physiological and pathological …
behavior, cell signaling, and cell matrix interactions in both physiological and pathological …