[HTML][HTML] Machine learning approaches to genome-wide association studies
Abstract Genome-wide Association Studies (GWAS) are conducted to identify single
nucleotide polymorphisms (variants) associated with a phenotype within a specific …
nucleotide polymorphisms (variants) associated with a phenotype within a specific …
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation
Pharmacogenetics (PGx) aims to optimize drug treatment outcomes by using a patient's
genetic profile for individualized drug and dose selection. Currently, reactive and …
genetic profile for individualized drug and dose selection. Currently, reactive and …
Analytical validation of GenoPharm a clinical genotyping open array panel of 46 pharmacogenes inclusive of variants unique to people of African ancestry
CR Kanji, BT Mbavha, C Masimirembwa… - Plos one, 2023 - journals.plos.org
Pharmacogenomic testing may be used to improve treatment outcomes and reduce the
frequency of adverse drug reactions (ADRs). Population specific, targeted …
frequency of adverse drug reactions (ADRs). Population specific, targeted …
Population genetic polymorphisms of pharmacogenes in Zimbabwe, a potential guide for the safe and efficacious use of medicines in people of African ancestry
BT Mbavha, CR Kanji, N Stadler, J Stingl… - Pharmacogenetics …, 2022 - journals.lww.com
Objective Pharmacogenomics (PGx) is a clinically significant factor in the safe and
efficacious use of medicines. While PGx knowledge is abundant for other populations, there …
efficacious use of medicines. While PGx knowledge is abundant for other populations, there …
The extent and impact of variation in ADME genes in sub-Saharan African populations
Introduction: Investigating variation in genes involved in the absorption, distribution,
metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic …
metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic …
AI can help to tailor drugs for Africa—but Africans should lead the way
Computational models that require very little data could transform biomedical and drug
development research in Africa, as long as infrastructure, trained staff and secure databases …
development research in Africa, as long as infrastructure, trained staff and secure databases …
[HTML][HTML] Allostery and missense mutations as intermittently linked promising aspects of modern computational drug discovery
Drug research and development is a multidisciplinary field with its own successes. Yet,
given the complexity of the process, it also faces challenges over the long development …
given the complexity of the process, it also faces challenges over the long development …
The role of pharmacogenomics studies for precision medicine among Ethiopian patients and their clinical implications: a scoping review
Background Pharmacogenomics research is currently revolutionizing treatment optimization
by discovering molecular markers. Medicines are the cornerstone of treatment for both acute …
by discovering molecular markers. Medicines are the cornerstone of treatment for both acute …
Promoting Pharmacogenomics in Africa: Perspectives From Variation in G6PD and Other Pharmacogenes.
BR Sitabule, H Othman, A Choudhury… - Clinical …, 2023 - search.ebscohost.com
African pharmacogenomics consortium: consolidating pharmacogenomics knowledge,
capacity development and translation in Africa: consolidating pharmacogenomics …
capacity development and translation in Africa: consolidating pharmacogenomics …
From Drug Discovery to Drug Approval: A Comprehensive Review of the Pharmacogenomics Status Quo with a Special Focus on Egypt
Pharmacogenomics (PGx) is the hope for the full optimization of drug therapy while
minimizing the accompanying adverse drug events that cost billions of dollars annually …
minimizing the accompanying adverse drug events that cost billions of dollars annually …