Patients with plasma cell dyscrasias produce free abnormal monoclonal immunoglobulin
light chains that circulate in the blood stream. Some of them, termed glomerulopathic light …

Amyloid diseases have become a global concern due to their increasing prevalence.
Transition metals, including copper, can affect the aggregation of the pathological proteins …

Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the
overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in …

The intrinsically disordered and amyloidogenic protein α-synuclein (AS) has been linked to
several neurodegenerative states, including Parkinson's disease. Here, nanoelectrospray …

α-Synuclein (α-Syn) aggregates are the major component of Lewy bodies (LB), which is a
pathological hallmark in the brain tissue of Parkinson's disease (PD) patients. It has been …

Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal
disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light …

Intervention into amyloid deposition with anti-amyloid agents like the polyphenol
epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment …

An extensive replica exchange molecular dynamics (REMD) simulation was performed to
investigate the progress patterns of the inhibition of (−)-epigallocatechin-3-gallate (EGCG) …

Light chain amyloidosis is the most common form of systemic amyloidosis. This disease is
caused by the formation and deposition of amyloid fibers made from immunoglobulin light …

Amyloid light‐chain (AL) amyloidosis is a rare disease in which plasma‐cell‐produced
monoclonal immunoglobulin light chains misfold and become deposited as fibrils in the …