The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

Several distinct pathological patterns of glomerular inflammation are associated with
abnormal regulation of the complement system, specifically, with dysregulation of the …

The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …

Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

Complement protein C1q, the recognition molecule of the classical pathway, performs a
diverse range of complement and non-complement functions. It can bind various ligands …

Systemic lupus erythematosus is a prototypic autoimmune disease characterized by
autoantibody production and immune complex formation/deposition in target organs such as …

Lupus nephritis (LN) represents the most severe organ manifestation of systemic lupus
erythematosus (SLE) in terms of morbidity and mortality. To reduce these risks, tremendous …

nomodulation of FcRs. 23 Some clues on how ICs may be atherogenic are emerging.
Oxidized lipids and antibodies to oxidized low-density lipoproteins (LDLs) are elevated in …