The identification and management of high-risk contaminants have raised great concern
from governments. Facing the growing amount of data on the occurrence of emerging …

Abstract Voltage-activated Na+(Na V) channels are crucial contributors to rapid electrical
signaling in the human body. As such, they are among the most targeted membrane proteins …

Deltamethrin (DM) is one of the extensively used pyrethroids for controlling ectoparasites.
Unfortunately, DM is highly toxic to fish as it primarily targets the sodium channels of the …

Emerging marine biotoxins such as ciguatoxins and pyrethroid compounds, widely used in
agriculture, are independently treated as environmental toxicants. Their maximum residue …

Carisbamate (CRS, RWJ-333369) is a new anti-seizure medication. It remains unclear
whether and how CRS can perturb the magnitude and/or gating kinetics of membrane ionic …

A microemulsion is a stable, homogeneous pesticide formulation, based on an aqueous
solvent, which is considered as a suitable alternative to emulsion formulations. In this study …

In a companion paper we examined whether combinations of K v 7 channel openers
(Retigabine and Diclofenac; RET, DIC) could be effective modifiers of deep tissue nociceptor …

Through the years, many synthetic or partially synthetic opioid agonists have also been
developed that are being employed in medicinal therapeutics. Mu, kappa and delta which …

KB-R7943, an isothiourea derivative, has been recognized as an inhibitor in the reverse
mode of the Na+-Ca2+ exchanging process. This compound was demonstrated to prevent …

Voltage-gated sodium channels (VGSC) in the peripheral nervous system shape action
potentials (AP) and thereby support the detection of sensory stimuli. Most of the nine …