The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

The R estoring I nsulin S ecretion (RISE) study was initiated to evaluate interventions to slow
or reverse the progression of β‐cell failure in type 2 diabetes (T2D). To design the RISE …

OBJECTIVE—We sought to determine whether an oral disposition index (DIO) predicts the
development of diabetes over a 10-year period. First, we assessed the validity of the DIO by …

The utility of the disposition index as a measure of β‐cell compensatory capacity rests on the
established hyperbolic relationship between its component insulin secretion and sensitivity …

Aims While the disposition index provides a useful measure of B‐cell function, its calculation
requires the performance of a frequently sampled intravenous glucose tolerance test …

OBJECTIVE To evaluate changes in insulin physiology in euglycemic pregnancy and
gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS Participants …

Supplementation with prebiotic polyphenol rutin is a potential dietary therapy for type 2
diabetes prevention in adults with obesity, based on previous glycaemic improvement in …

Aims/hypothesis This study aimed to perform a comprehensive analysis of interlobular,
intralobular and parenchymal pancreatic fat in order to assess their respective effects on …

OBJECTIVE β-Cell mass declines progressively during the course of diabetes, and various
antidiabetic treatment regimens have been suggested to modulate β-cell mass. However …

OBJECTIVE To examine β-cell function across a spectrum of glycemia among Asian Indians,
a population experiencing type 2 diabetes development at young ages despite low BMI …