Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of
human neoplasms. Their clinical success is, however, limited due to severe side effects and …

Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to
be in widespread clinical use especially for management of tumors of the ovary, testes, and …

Since its approval in 1979 cisplatin has become an important component in chemotherapy
regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

The many activities of metal ions in biology have stimulated the development of metal-based
therapeutics. Cisplatin, as one of the leading metal-based drugs, is widely used in treatment …

Over twenty years of intensive work toward improvement of cisplatin, and with hundreds of
platinum drugs tested, has resulted in the introduction of the widely used carboplatin and of …

Platinum drugs comprise of almost 50% of all currently used anticancer drugs. They are now
widely used in the clinical therapy of various solid tumors, including ovarian, head and neck …

The application of inorganic chemistry to medicine is a rapidly developing field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …

Cellular DNA is susceptible to chemical modifications when exposed to various
environmental agents, chemotherapeutic agents, or endogenous agents produced by …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …