ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'

T Padro, O Manfrini, R Bugiardini, J Canty… - Cardiovascular …, 2020 - academic.oup.com
Although myocardial ischaemia usually manifests as a consequence of atherosclerosis-
dependent obstructive epicardial coronary artery disease, a significant percentage of …

Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

[HTML][HTML] Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier

MS Poomani, I Mariappan, R Perumal, R Regurajan… - Global Heart, 2022 - ncbi.nlm.nih.gov
Although tremendous progress has been made in conventional treatment for ischemic heart
disease, it still remains a major cause of death and disability. Cell-based therapeutics holds …

Adipose tissue depots and inflammation: effects on plasticity and resident mesenchymal stem cell function

L Badimon, J Cubedo - Cardiovascular research, 2017 - academic.oup.com
Adipose tissue (AT) is a highly heterogeneous organ. Beside the heterogeneity associated
to different tissue types (white, brown, and 'brite') and its location-related heterogeneity …

Microvascular experimentation in the chick chorioallantoic membrane as a model for screening angiogenic agents including from gene-modified cells

DC Kennedy, B Coen, AM Wheatley… - International journal of …, 2021 - mdpi.com
The chick chorioallantoic membrane (CAM) assay model of angiogenesis has been
highlighted as a relatively quick, low cost and effective model for the study of pro-angiogenic …

The roles of nanoparticles in stem cell-based therapy for cardiovascular disease

Y Sun, Y Lu, L Yin, Z Liu - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Cardiovascular disease (CVD) is currently one of the primary causes of mortality and
morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in …

MicroRNA-145 regulates the differentiation of adipose stem cells toward microvascular endothelial cells and promotes angiogenesis

G Arderiu, E Peña, R Aledo, O Juan-Babot… - Circulation …, 2019 - Am Heart Assoc
Rationale: Adipose-derived stem cells (ASCs) are a potential adult mesenchymal stem cell
source for restoring endothelial function in ischemic tissues. However, the mechanism that …

Future perspectives on the role of stem cells and extracellular vesicles in vascular tissue regeneration

EM Cunnane, JS Weinbaum, FJ O'Brien… - Frontiers in …, 2018 - frontiersin.org
Vascular tissue engineering is an area of regenerative medicine that attempts to create
functional replacement tissue for defective segments of the vascular network. One approach …

Microvasculature recovery by angiogenesis after myocardial infarction

L Badimon, M Borrell - Current pharmaceutical design, 2018 - ingentaconnect.com
Advances in early reperfusion therapies focused on the revascularization of the ischemic
tissues, in the last decades, lead to reduced mortality in acute myocardial infarction (MI) …

[HTML][HTML] Mesenchymal stem cells inhibit T cell activation by releasing TGF-β1 from TGF-β1/GARP complex

J Niu, W Yue, Z Le-Le, L Bin, X Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Intervention with mesenchymal stem cells (MSCs) reveals a promising therapeutic tool to
treat transplantation and autoimmune disease due to their immunoregulation capability. But …