Notch signaling pathway: architecture, disease, and therapeutics
B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
Notch as a tumour suppressor
CS Nowell, F Radtke - Nature Reviews Cancer, 2017 - nature.com
The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …
in regulating development and homeostasis in various tissues. The cellular processes and …
CODA: quantitative 3D reconstruction of large tissues at cellular resolution
A central challenge in biology is obtaining high-content, high-resolution information while
analyzing tissue samples at volumes relevant to disease progression. We address this here …
analyzing tissue samples at volumes relevant to disease progression. We address this here …
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer
Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-
acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma …
acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma …
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
Notch signalling in solid tumours: a little bit of everything but not all the time
P Ranganathan, KL Weaver, AJ Capobianco - Nature Reviews Cancer, 2011 - nature.com
The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …
an ever-widening understanding of cellular processes that are controlled or influenced by …
To differentiate or not—routes towards metastasis
T Brabletz - Nature Reviews Cancer, 2012 - nature.com
Why are many metastases differentiated? Invading and disseminating carcinoma cells can
undergo an epithelial–mesenchymal transition (EMT), which is associated with a gain of …
undergo an epithelial–mesenchymal transition (EMT), which is associated with a gain of …
From fly wings to targeted cancer therapies: a centennial for notch signaling
Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …
[HTML][HTML] EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma
C Navas, I Hernández-Porras, AJ Schuhmacher… - Cancer cell, 2012 - cell.com
Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually
exclusive with the presence of K-RAS oncogenes in lung and colon tumors. We have …
exclusive with the presence of K-RAS oncogenes in lung and colon tumors. We have …
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer
Background & Aims As in other tumor types, progression of pancreatic cancer may require a
functionally unique population of cancer stem cells. Although such cells have been identified …
functionally unique population of cancer stem cells. Although such cells have been identified …