Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

Drug-transporter interactions could impact renal drug clearance and should ideally be
detected in early stages of drug development to avoid toxicity-related withdrawals in later …

Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the
worldwide emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2), drug …

Cyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a
large variety of biological processes. The most abundant member of this enzyme family …

Many chemotherapeutic drugs suffer from multidrug resistance (MDR). Efflux transporters,
namely ATP-binding cassettes (ABCs), that pump the drugs out of the cancer cells comprise …

Membrane transporters play an essential role in the pharmacokinetics of drugs as they
mediate exchanges between biological compartments. Tacrolimus is characterized by wide …

Background: Serum urate (SU) levels in primates are extraordinarily high among mammals.
Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but …

Ischemia-reperfusion (IR)-induced acute kidney injury (IRI) is an inevitable event in kidney
transplantation. It is a complex pathophysiological process associated with numerous …