Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Highlights•The versatile chemistry of the flavin cofactor underpins a wide range of enzyme
reactions.•New flavin species have recently been discovered, including prenylated flavins …

Coenzymes are ubiquitous in Nature, assisting in enzyme-catalysed reactions. Several
coenzymes, nicotinamides and flavins, have been known for close to a century, whereas …

By a targeted enzyme engineering approach, we were able to create an efficient NADPH
oxidase from a monooxygenase. Intriguingly, replacement of only one specific single amino …

Two-component flavoprotein monooxygenases consist of a reductase and an oxygenase
enzyme. The proof of functionality of the latter without its counterpart as well as the …

In the biosynthesis of pentalenolactone (1), PenE and PntE, orthologous proteins from
Streptomyces exfoliatus and S. arenae, respectively, catalyze the flavin-dependent Baeyer …

Baeyer-Villiger monooxygenases (BVMOs) are flavin-dependent enzymes that primarily
convert ketones to esters, but can also catalyze heteroatom oxidation. Several structural …

This PhD thesis describes research in the field of biocatalysis. We use enzymes, ie proteins
that facilitate chemical transformations in living organisms, and explore their potential for …