Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever
Summary Myosin 5a (Myo5a) is a dimeric processive motor protein that transports cellular
cargos along filamentous actin (F-actin). Its long lever is responsible for its large power …
cargos along filamentous actin (F-actin). Its long lever is responsible for its large power …
Myosin-1C differentially displaces tropomyosin isoforms altering their inhibition of motility
LW Pollard, M Boczkowska, R Dominguez… - Journal of Biological …, 2024 - jbc.org
Force generation and motility by actomyosin in nonmuscle cells are spatially regulated by∼
40 tropomyosin (Tpm) isoforms. The means by which Tpms are targeted to specific cellular …
40 tropomyosin (Tpm) isoforms. The means by which Tpms are targeted to specific cellular …
Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
MJ Rynkiewicz, MC Childers, OE Karpicheva… - Journal of General …, 2024 - rupress.org
Dynamic interactions between the myosin motor head on thick filaments and the actin
molecular track on thin filaments drive the myosin-crossbridge cycle that powers muscle …
molecular track on thin filaments drive the myosin-crossbridge cycle that powers muscle …
[HTML][HTML] Dynamics of the Pre-Powerstroke Myosin Lever Arm and the Effects of Omecamtiv Mecarbil
MC Childers, M Regnier - International Journal of Molecular Sciences, 2024 - mdpi.com
The binding of small molecules to sarcomeric myosin can elicit powerful effects on the
chemomechanical cycle, making them effective therapeutics in the clinic and research tools …
chemomechanical cycle, making them effective therapeutics in the clinic and research tools …
Human cardiac β-myosin powerstroke energetics: Thin filament, Pi displacement, and mutation effects
The powerstroke of human cardiac β-myosin is an important stage of the cross-bridge cycle
that generates force for muscle contraction. However, the starting structure of this process …
that generates force for muscle contraction. However, the starting structure of this process …