Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
J Morales, S Pujar, JE Loveland, A Astashyn, R Bennett… - Nature, 2022 - nature.com
Comprehensive genome annotation is essential to understand the impact of clinically
relevant variants. However, the absence of a standard for clinical reporting and browser …
relevant variants. However, the absence of a standard for clinical reporting and browser …
Position-dependent function of human sequence-specific transcription factors
SH Duttke, C Guzman, M Chang, NP Delos Santos… - Nature, 2024 - nature.com
Patterns of transcriptional activity are encoded in our genome through regulatory elements
such as promoters or enhancers that, paradoxically, contain similar assortments of …
such as promoters or enhancers that, paradoxically, contain similar assortments of …
Structural insights into preinitiation complex assembly on core promoters
INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes
CWQ Koh, YT Goh, WSS Goh - Nature communications, 2019 - nature.com
Various methyltransferases and demethylases catalyse methylation and demethylation of N
6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine (m6Am) but precise …
6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine (m6Am) but precise …
Identification and dynamic quantification of regulatory elements using total RNA
The spatial and temporal regulation of transcription initiation is pivotal for controlling gene
expression. Here, we introduce capped-small RNA-seq (csRNA-seq), which uses total RNA …
expression. Here, we introduce capped-small RNA-seq (csRNA-seq), which uses total RNA …
Structural visualization of transcription initiation in action
X Chen, W Liu, Q Wang, X Wang, Y Ren, X Qu, W Li… - Science, 2023 - science.org
Transcription initiation is a complex process, and its mechanism is incompletely understood.
We determined the structures of de novo transcribing complexes TC2 to TC17 with RNA …
We determined the structures of de novo transcribing complexes TC2 to TC17 with RNA …
HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression
S Srinivasachar Badarinarayan… - Nucleic Acids …, 2020 - academic.oup.com
Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements,
their role in modulating cellular immune responses remains poorly understood. Using an …
their role in modulating cellular immune responses remains poorly understood. Using an …
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis
Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing
across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24 …
across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24 …