TNF/TNFR family members in costimulation of T cell responses

TH Watts - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

M Croft - Nature Reviews Immunology, 2003 - nature.com
Interactions between co-stimulatory ligands and their receptors are crucial for the activation
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now …

CD27 is required for generation and long-term maintenance of T cell immunity

J Hendriks, LA Gravestein, K Tesselaar… - Nature …, 2000 - nature.com
The Traf-linked tumor necrosis factor receptor family member CD27 is known as a T cell
costimulatory molecule. We generated CD27−/− mice and found that CD27 makes essential …

CD27 and CD70 in T cell and B cell activation

J Borst, J Hendriks, Y Xiao - Current opinion in immunology, 2005 - Elsevier
In vitro work has defined the TNF receptor family member CD27 as a T and B cell co-
stimulatory molecule. Its activity is governed by the transient availability of its TNF-like ligand …

A logical model provides insights into T cell receptor signaling

J Saez-Rodriguez, L Simeoni… - PLoS computational …, 2007 - journals.plos.org
Cellular decisions are determined by complex molecular interaction networks. Large-scale
signaling networks are currently being reconstructed, but the kinetic parameters and …

Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells

GRA Ehrhardt, JT Hsu, L Gartland, CM Leu… - The Journal of …, 2005 - rupress.org
The FcRH4 transmembrane molecule, a member of the Fc receptor homologue family, can
potently inhibit B cell receptor (BCR) signaling. We show that cell surface expression of this …

Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

MA Nolte, RW Van Olffen… - Immunological …, 2009 - Wiley Online Library
After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis
factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates …

TNF receptor associated factor 2 (TRAF2) signaling in cancer

D Siegmund, J Wagner, H Wajant - Cancers, 2022 - mdpi.com
Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators

H Wajant, F Henkler, P Scheurich - Cellular signalling, 2001 - Elsevier
The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of
scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling …

Control of T cell viability

P Marrack, J Kappler - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract The factors affecting T cell viability vary depending on the type and status of the T
cell involved. Naïve T cells die via a Bcl-2/Bim dependent route. Their deaths are prevented …