Mathematical models are routinely calibrated to experimental data, with goals ranging from
building predictive models to quantifying parameters that cannot be measured. Whether or …

Reaction-diffusion systems have been widely used to study spatio-temporal phenomena in
cell biology, such as cell polarization. Coupled bulk-surface models naturally include …

Cells polarize for growth, motion, or mating through regulation of membrane-bound small
GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP …

The highly conserved small GTPase Cdc42 regulates polarized cell growth and
morphogenesis from yeast to humans. We previously reported that Cdc42 activation exhibits …

The expression of individual genes into functional protein molecules is a noisy dynamical
process. Here we model the protein concentration as a jump-drift process which combines …

We provide a short review of stochastic modeling in chemical reaction networks for
mathematical and quantitative biologists. We use as case studies two publications …

In confined spaces, migrating cells can undergo mesenchymal-to-amoeboid transitions by
altering their cortical dynamics and adhesion with the environment. Septins frequently …

Sažetak Male GTPaze iz obitelji Rho predstavljaju skupinu signalnih proteina odgovornih za
regulaciju i koordinaciju brojnih staničnih aktivnosti vođenih aktinskim citoskeletom. Među …

Motivated by the spatial segregation of intracellular proteins between the cytoplasm and the
cellular membrane, we investigate the spatio-temporal dynamics of coupled bulk-surface …