Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Simple Summary Lung cancer is the leading cause of cancer-related death worldwide, with
an average 5-year survival rate of approximately 15%. Among the multiple histological type …

Characterizing the stem cells responsible for lung repair and regeneration is important for
the treatment of pulmonary diseases. Recently, a unique cell population located at the …

Lung stem cells are instructed to produce lineage-specific progeny through unknown factors
in their microenvironment. We used clonal 3D cocultures of endothelial cells and distal lung …

Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Bronchioalveolar stem cells (BASC s) are a potential source for lung regeneration, but direct
in vivo evidence for a multipotential lineage contribution during homeostasis and disease is …

Overwhelming evidence indicates that virtually all treatment-naive tumors contain a
subpopulation of cancer cells that possess some stem cell traits and properties and are …

Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)–induced lung
adenocarcinoma. To shed light on this issue, we have used technology that enables us to …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …