In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with
no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …

De novo mutations in CHD8 are strongly associated with autism spectrum disorder, but the
basic biology of CHD8 remains poorly understood. Here we report that Chd8 knockdown …

Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

During mammalian cerebral cortex development, the G1-phase of the cell cycle is known to
lengthen, but it has been unclear which neural stem and progenitor cells are affected. In this …