Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control.
However, the mechanisms by which Parkin connects mitochondrial homeostasis with …

Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been
implicated in the prevention of obesity, its molecular actions in adipocytes remain …

High-fat diet (HFD) is associated with Alzheimer's disease (AD) and type 2 diabetes risk,
which share features such as insulin resistance and amylin deposition. We examined gene …

Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …

Background Studies looking at associations between environmental chemicals and child
behaviour usually consider only one exposure or family of exposures. Objective This study …

Obesity is associated with widespread differential DNA methylation (DNAm) patterns, though
there have been limited overlap in the obesity‐associated cytosine–guanine nucleotide pair …

Diabetes is a severe threat to global health. Almost 500 million people live with diabetes
worldwide. Most of them have type 2 diabetes (T2D). T2D patients are at risk of developing …