Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …

Traditional Chinese medicines (TCM) have recently been recognized as a new source of
anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy …

Metal complexes afford an opportunity for the discovery of new antitumour drugs with truly
novel mechanisms of action. Various tactics and some new concepts have been employed …

Cis-diamminedichloroplatinum II (CDDP)-induced nephrotoxicity is associated with the
overproduction of reactive oxygen species. tert-Butylhydroquinone (tBHQ) is a compound …

Liposomes have been employed as carriers for antineoplastic drugs to improve delivery. We
describe an HPLC–UV method for determining cisplatin levels in liposomal and biological …

Palladium-based compounds are regarded as potential analogs to platinum anticancer
drugs with improved properties. The present study assessed the pharmacokinetics and …

Cyanide represents a persistent threat for accidental or malicious misuse due to easy
conversion into a toxic gas and access to large quantities through several industries. The …

Four unsaturated norcantharimide (UNCI) dimers were synthesized and characterized by
elemental analysis, ESI-QTOF-MS, FT/IR, UV–Vis, 1 H and 13 C NMR as well as single …

A series of novel platinum (II) complexes involving a carrier with HO–peripheral functional
group, 2-hydroxy-1, 3-propanediamine (HO-pda), cis-[Pt (HO-dpa) X2](X2= 2Cl−(1), C2O42 …

Two new mixed-ligand complexes [M (atdz)(DCA)(H2O) 2]· 2H2O,(M= Co (II), Zn (II); atdz= 2-
amino-1, 3, 4-thiadiazole, C2H3N3S; DCA= demethylcantharate, 7-oxabicyclo [2, 2, 1] …