The field of paramagnetic NMR has expanded considerably in recent years. This review
addresses both the theoretical description of paramagnetic NMR, and the way in which it is …

Although scalar-coupling provides important structural information, the resulting signal
splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular …

Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …

Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …

Many cell signaling events are coordinated by intrinsically disordered protein regions (IDRs)
that undergo multisite Serine/Threonine phosphorylation. The conformational properties of …

This article deals with the solution structure determination of paramagnetic metalloproteins
by NMR spectroscopy. These proteins were believed not to be suitable for NMR …

Recent advances in NMR methodology and techniques allow the structural investigation of
biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

In recent years considerable effort has been devoted to increasing the success rate of the
drug discovery process [1–7]. The focus has been mainly on quantity and speed …