Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

miRNAs as cornerstones in adipogenesis and obesity

SY Elkhawaga, A Ismail, EGE Elsakka, AS Doghish… - Life Sciences, 2023 - Elsevier
In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …

MicroRNA regulatory networks in human adipose tissue and obesity

P Arner, A Kulyté - Nature Reviews Endocrinology, 2015 - nature.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and,
therefore, biological processes in different tissues. A major function of miRNAs in adipose …

MicroRNAs in obesity and related metabolic disorders

JF Landrier, A Derghal, L Mounien - Cells, 2019 - mdpi.com
Metabolic disorders are characterized by the inability to properly use and/or store energy.
The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through …

Adipose tissue microRNAs as regulators of CCL2 production in human obesity

E Arner, N Mejhert, A Kulyté, PJ Balwierz… - Diabetes, 2012 - Am Diabetes Assoc
In obesity, white adipose tissue (WAT) inflammation is linked to insulin resistance. Increased
adipocyte chemokine (CC motif) ligand 2 (CCL2) secretion may initiate adipose …

microRNAs in the regulation of adipogenesis and obesity

R A. McGregor, M S. Choi - Current molecular medicine, 2011 - benthamdirect.com
Worldwide obesity is a growing health problem, associated with increased risk of chronic
disease. Understanding the molecular basis of adipogenesis and fat cell development in …

Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis

LE Zaragosi, B Wdziekonski, KL Brigand, P Villageois… - Genome biology, 2011 - Springer
Background In severe obesity, as well as in normal development, the growth of adipose
tissue is the result of an increase in adipocyte size and numbers, which is underlain by the …

Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α

A Meerson, M Traurig, V Ossowski, JM Fleming… - Diabetologia, 2013 - Springer
Aims/hypothesis MicroRNAs (miRNAs) are short endogenous RNAs that regulate multiple
biological processes including adipogenesis and fat metabolism. We sought to identify …

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

S Lorente-Cebrián, P González-Muniesa… - Clinical …, 2019 - portlandpress.com
Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …

Exercise training-induced changes in microRNAs: beneficial regulatory effects in hypertension, type 2 diabetes, and obesity

AC Improta Caria, CKV Nonaka, CS Pereira… - International journal of …, 2018 - mdpi.com
MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally.
They are involved in the regulation of physiological processes, such as adaptation to …