Selected reaction monitoring (SRM) has a long history of use in the area of quantitative MS.
In recent years, the approach has seen increased application to quantitative proteomics …

The sensitive and specific detection of peptides at low levels in biofluids is critical to
increase the lab-to-human translation of peptidomic research. An interesting group of …

Large-scale proteomics often employs two orthogonal separation methods to fractionate
complex peptide mixtures. Fractionation can involve ion exchange separation coupled to …

Background: Intact insulins are difficult to analyze by LC–MS/MS due to nonspecific binding
and poor sensitivity, solubility and fragmentation. This work aims to provide a simpler, faster …

Analytical method development for peptides often proves challenging since these molecules
can adsorb to the plastic or glass consumables used in the analysis. This adsorption causes …

Background The synthesis of bioactive nanoparticles with precise molecular level control is
a major challenge in bionanotechnology. Understanding the nature of the interactions …

The dry period is necessary to facilitate cell turnover in the bovine mammary gland and to
optimize milk production in the next lactation. An 8‐week dry period has long been the …

The recent increase in peptidomimetic-based medications and the growing interest in
peptide hormones has brought new attention to the quantification of peptides for diagnostic …

To prevent possible frauds and give more protection to companies and consumers it is
necessary to control that the types of milk used in the elaboration of dairy products …

A wide variety of hydrophilic interaction chromatography (HILIC) stationary phase surface
chemistries are currently available. Although their selectivity can be considerably different …