The successful maternal tolerance of the semi-allogeneic fetus provides an apparent
immunologic paradox. Indeed, deep invasion of placental trophoblast cells into maternal …

Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility
complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily …

Placenta accreta spectrum (PAS) is a high-risk obstetrical condition associated with
significant morbidity and mortality. Current clinical screening modalities for PAS are not …

Reproductive physiology and immunology as scientific disciplines each have rich, largely
independent histories. The physicians and philosophers of ancient Greece made …

Placentation is an immunological compromise where maternal immune system cells and
trophoblastic cells interact to reach an equilibrium condition. Although the cross talk …

Recurrent pregnancy loss (RPL) affects 1–2% of couples who are trying to conceive. At
some point, some couples do maintain a healthy pregnancy to term, but the underlying …

The main role of HLA-G is to protect the semi-allogeneic embryo from immune rejection by
proper interaction with its cognate receptors on the maternal immune cells. Spontaneous …

Problem The immune system plays an essential role in embryonic implantation and
pregnancy, but the molecular details remain controversial. In the past four decades, human …

The juxtaposition of two seemingly disparate physiological phenomena within the human
body—namely, cancer and pregnancy—may offer profound insights into the intricate …

Abstract Problem Recurrent Pregnancy Loss (RPL) is a disorder characterized by two or
more pregnancy losses within 20th week of gestation. Globally 1–5% of the couples are …