Bioactive or nutraceutical ingredients have been widely used in pursuit of health and well-
being. However, the environmental instability, poor solubility and bioavailability, and …

Proteolysis targeting chimeras (PROTACs) represent a transformative class of therapeutic
agents that leverage the intrinsic protein degradation machinery to modulate the hemostasis …

Exploring the response of malignant cells to intracellular metabolic stress is critical for
understanding pathologic processes and developing anticancer therapies. Herein, we …

Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus
demands, which vary during gestation. The present study describes the changes in maternal …

Herein, we report on the successful encapsulation into human H-ferritin of two highly
charged Ru (II) polypyridyl complexes,[Ru (phen) 2L′] 2+(Ru1, with L′= 4, 4′-(2, 5, 8, 11 …

An optimal fatty acid (FA) profile during pregnancy, especially docosahexaenoic acid (DHA)
and eicosapentaenoic acid (EPA), is essential for the health of the mother and child. Our aim …

Epirubicin (Epr) is an effective chemotherapeutic drug; however, the clinical amenability of
Epr is limited by its highly toxic interaction with normal cells. This toxicity can be decreased …

Ferritin is a universal macromolecule protein that stores iron and regulates iron oxidative
deposition and release. The physicochemical properties of ferritin can be affected by …

Cage forming proteins have numerous potential applications in biomedicine and
biotechnology, where the iron storage ferritin is a widely used example. However, controlling …

Background: The intrinsically disordered, amyloidogenic protein Tau associates with diverse
classes of molecules, including proteins, nucleic acids, and lipids. Mounting evidence …