Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Modelling for digital twins—potential role of surrogate models

A Barkanyi, T Chovan, S Nemeth, J Abonyi - Processes, 2021 - mdpi.com
The application of white box models in digital twins is often hindered by missing knowledge,
uncertain information and computational difficulties. Our aim was to overview the difficulties …

A novel long short-term memory artificial neural network (LSTM)-based soft-sensor to monitor and forecast wastewater treatment performance

B Xu, CK Pooi, KM Tan, S Huang, X Shi… - Journal of Water Process …, 2023 - Elsevier
Commercial instrumentation for measurement of various wastewater treatment processes
parameters is costly and time-consuming in wastewater treatment plants (WWTPs). Long …

Linking models and experiments

D Bonvin, C Georgakis, CC Pantelides… - Industrial & …, 2016 - ACS Publications
This position paper gives an overview of the discussion that took place at FIPSE 2 at
Aldemar Resort, east of Heraklion, Crete, in June 21–23, 2014. This is the second …

Semi-supervised adaptive PLS soft-sensor with PCA-based drift correction method for online valuation of NOx emission in industrial water-tube boiler

SH Hasnen, M Shahid, H Zabiri, SAA Taqvi - Process Safety and …, 2023 - Elsevier
The use of soft sensors for the prediction of Nitric Oxides (NOx) emissions to meet quality
regulations has become increasingly attractive from the economic point of view. However …

[HTML][HTML] Machine learning for industrial sensing and control: A survey and practical perspective

NP Lawrence, SK Damarla, JW Kim, A Tulsyan… - Control Engineering …, 2024 - Elsevier
With the rise of deep learning, there has been renewed interest within the process industries
to utilize data on large-scale nonlinear sensing and control problems. We identify key …

Design and applications of soft sensors in polymer processing: A review

C Abeykoon - IEEE Sensors Journal, 2018 - ieeexplore.ieee.org
In manufacturing industry, process monitoring is a key to observe the product quality,
operational health, safety, and also for achieving good/satisfactory process control …

Semi-supervised online soft sensor maintenance experiences in the chemical industry

B Lu, L Chiang - Journal of Process Control, 2018 - Elsevier
With the increasing availability of spectral, vibrational, thermal and other sensors, the
challenge of “Big Data” in chemical processing industry is not only to analyze the data …

A hybrid modeling approach for catalyst monitoring and lifetime prediction

L Bui, M Joswiak, I Castillo, A Phillips, J Yang… - ACS Engineering …, 2021 - ACS Publications
In this work, we present a hybrid fundamental-empirical model to monitor and predict the
catalyst lifetime of an operating industrial reactor. The hybrid model combines a fundamental …

Dual learning-based online ensemble regression approach for adaptive soft sensor modeling of nonlinear time-varying processes

H Jin, X Chen, L Wang, K Yang, L Wu - Chemometrics and Intelligent …, 2016 - Elsevier
Soft sensors have been widely used to estimate difficult-to-measure variables in the process
industry. However, the nonlinear nature and time-varying behavior of many processes pose …