Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap

F Daneshnia, JN de Almeida Júnior, M Ilkit… - The Lancet …, 2023 - thelancet.com
Candida parapsilosis is one of the most commen causes of life-threatening candidaemia,
particularly in premature neonates, individuals with cancer of the haematopoietic system …

Candida parapsilosis complex in the clinical setting

M Govrins, C Lass-Flörl - Nature Reviews Microbiology, 2024 - nature.com
Representatives of the Candida parapsilosis complex are important yeast species causing
human infections, including candidaemia as one of the leading diseases. This complex …

[HTML][HTML] European candidaemia is characterised by notable differential epidemiology and susceptibility pattern: Results from the ECMM Candida III study

MC Arendrup, S Arikan-Akdagli, KM Jørgensen… - Journal of Infection, 2023 - Elsevier
The objectives of this study were to assess Candida spp. distribution and antifungal
resistance of candidaemia across Europe. Isolates were collected as part of the third ECMM …

Candida parapsilosis sensu stricto Antifungal Resistance Mechanisms and Associated Epidemiology

I Franconi, C Rizzato, N Poma, A Tavanti, A Lupetti - Journal of Fungi, 2023 - mdpi.com
Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has
become a matter of great concern in public health. In recent years rates of non-albicans …

Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational …

PJT Brassington, FR Klefisch, B Graf, R Pfüller… - The Lancet …, 2025 - thelancet.com
Summary Background Fluconazole-resistant Candida parapsilosis has emerged as a
significant health-care-associated pathogen with a propensity to spread patient to patient …

Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis

L Sun, H Li, T Yan, Y Cao, Y Jiang, F Yang - Frontiers in Microbiology, 2023 - frontiersin.org
Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-
line antifungal drugs for the treatment of invasive Candida infections. In clinical isolates …

[HTML][HTML] Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of …

F Daneshnia, A Arastehfar, L Lombardi… - International journal of …, 2023 - Elsevier
Candida parapsilosis is a significant cause of candidemia worldwide. Echinocandin-
resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been …

Whole-genome sequencing confirms a persistent candidaemia clonal outbreak due to multidrug-resistant Candida parapsilosis

F Daneshnia, S Hilmioğlu-Polat, M Ilkit… - Journal of …, 2023 - academic.oup.com
Objectives Although perceived as a rare clinical entity, recent studies have noted the
emergence of MDR C. parapsilosis (MDR-Cp) isolates from single patients (resistant to both …

Emergence of multiple fluconazole-resistant Candida parapsilosis sensu stricto clones with persistence and transmission in China

YT Ning, TS Sun, RC Dai, ZY Luo, SY Yu… - Journal of …, 2024 - academic.oup.com
Objectives We explored the epidemiological and molecular characteristics of Candida
parapsilosis sensu stricto isolates in China, and their mechanisms of azole resistance …

Predictors for Prolonged Hospital Stay Solely to Complete Intravenous Antifungal Treatment in Patients with Candidemia: Results from the ECMM Candida III …

M Egger, J Salmanton-García, A Barac, JP Gangneux… - Mycopathologia, 2023 - Springer
Background To date, azoles represent the only viable option for oral treatment of invasive
Candida infections, while rates of azole resistance among non-albicans Candida spp …