The metal-catalyzed asymmetric conjugate addition (ACA) reaction has emerged as a
general and powerful approach for the construction of optically active compounds and is …

A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …

Conjugate addition is among the most important synthetic protocols for constructing carbon
skeletons and is widely used to synthesize natural products and drugs. However …

Effective differentiation of prochiral carbon–hydrogen (C–H) bonds on a single methylene
carbon via asymmetric metal insertion remains a challenge. Here, we report the discovery of …

Stereochemical control in the construction of carbon-carbon bonds between an alkyl
electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis …

A catalytic asymmetric conjugate hydrophosphination of α, β-unsaturated amides is
accomplished by virtue of the strong nucleophilicity of copper (I)-PPh2 species, which …

Chiral iminium ions—generated upon condensation of α, β-unsaturated aldehydes and
amine catalysts—are used extensively by chemists to make chiral molecules in …

An organocatalytic enantioselective radical reaction of potassium alkyltrifluoroborates,
DABCO·(SO2) 2 and α, β-unsaturated carbonyl compounds under photoinduced conditions …

A bis (imino) pyridine cobalt-catalyzed hydroboration of terminal alkynes with HBPin (Pin=
pinacolate) with high yield and (Z)-selectivity for synthetically valuable vinylboronate esters …

We report here a stereodivergent method for the Michael addition of aryl acetic acid esters to
α, β-unsaturated aldehydes catalyzed by a combination of a chiral pyrrolidine and a chiral …