Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Only three biological pathways are known to produce oxygen: photosynthesis, chlorate
respiration and the detoxification of reactive oxygen species. Here we present evidence for a …

Peroxynitrite is formed by the very fast reaction of nitric oxide and superoxide radicals, a
reaction that kinetically competes with other routes that chemically consume or physically …

Fatty liver disease is one of the most prevalent forms of chronic liver disease that
encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …

Superoxide dismutases (SODs) are a family of metalloenzymes that catalyze the dismutation
or disproportionation of superoxide radicals (O _ 2^ ⋅-O 2·-) into molecular oxygen (O 2) …

Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

Oxidative stress plays a key role in the pathogenesis of aging and many metabolic diseases;
therefore, an effective antioxidant therapy would be of great importance in these …

Significance: Among different forms of oxidative stress, lipid peroxidation comprises the
interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the …