During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …

In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in
amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the …

From tumorigenesis to advanced metastatic stages, tumor cells encounter stress, ranging
from limited nutrient and oxygen supply within the tumor microenvironment to extrinsic and …

Neurodegenerative diseases are characterized by the presence of protein inclusions with a
different protein content depending on the type of disease. Amyotrophic lateral sclerosis …

We evaluated whether specifically and directly targeting human antigen R (HuR), a member
of embryonic lethal abnormal vision (ELAV) proteins family, may represent a new potential …

Alteration in RNA metabolism, concerning both coding and long non-coding RNAs
(lncRNAs), may play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis …

Debilitating cancer-induced muscle wasting, a syndrome known as cachexia, is lethal. Here
we report a posttranscriptional pathway involving the RNA-binding protein HuR as a key …

Retinal neurons are not able to undergo spontaneous regeneration in response to damage.
A variety of stressors, ie, UV radiation, high temperature, ischemia, allergens, and others …

Methionine is a rate-limiting amino-acid for protein synthesis but non-proteinogenic roles on
lipid metabolism and oxidative stress have been demonstrated. Contrary to rodents where a …

Copper (Cu) is an essential micronutrient with a critical role in mammalian growth and
development. Imbalance of Cu causes severe diseases in humans; therefore, cellular Cu …