Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy

B Kalita, YN Utkin, AK Mukherjee - Toxins, 2022 - mdpi.com
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …

Snake venom peptides and low mass proteins: molecular tools and therapeutic agents

JR Almeida, LM Resende, RK Watanabe… - Current medicinal …, 2017 - ingentaconnect.com
Snake venoms are natural sources of biologically active molecules that are able to act
selectively and specifically on different cellular targets, modulating physiological functions …

The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer

E Khatoon, M Hegde, A Kumar, UD Daimary… - Archives of Pharmacal …, 2022 - Springer
Oral cancer is one of the leading causes of cancer-related deaths, and it has become a
matter of serious concern due to the alarming rise in its incidence rate worldwide. Despite …

Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application

MI Estevão-Costa, R Sanz-Soler… - The international journal …, 2018 - Elsevier
Both mythologically and logically, snakes have always fascinated man. Snakes have
attracted both awe and fear not only because of the elegant movement of their limbless …

Mitochondrial alterations and oxidative stress in an acute transient mouse model of muscle degeneration: implications for muscular dystrophy and related muscle …

R Ramadasan-Nair, N Gayathri, S Mishra… - Journal of Biological …, 2014 - ASBMB
Muscular dystrophies (MDs) and inflammatory myopathies (IMs) are debilitating skeletal
muscle disorders characterized by common pathological events including myodegeneration …

[HTML][HTML] The myth of cobra venom cytotoxin: More than just direct cytolytic actions

JJ Hiu, MKK Yap - Toxicon: X, 2022 - Elsevier
Cobra venom cytotoxin (CTX) is a non-enzymatic three-finger toxin that constitutes 40–60%
of cobra venom. Thus, it plays an important role in the pathophysiology of cobra …

Structure and dynamics of cardiotoxins

AG Konshina, PV Dubovskii… - Current Protein and …, 2012 - ingentaconnect.com
Cytotoxins (or cardiotoxins; CTs) are toxins from cobra venom characterized by the three-
finger (TF) fold. CTs are on average 60-residue-long peptides, possessing as many as 4 …

Cobra cardiotoxins: Membrane interactions and pharmacological potential

P V. Dubovskii, A G. Konshina… - Current medicinal …, 2014 - benthamdirect.com
Natural polycationic membrane-active peptides typically lack disulfide bonds and exhibit
fusion, cellpenetrating, antimicrobial activities. They are mostly unordered in solution, but …

Targeting metastasis with snake toxins: molecular mechanisms

FA Urra, R Araya-Maturana - Toxins, 2017 - mdpi.com
Metastasis involves the migration of cancer cells from a primary tumor to invade and
establish secondary tumors in distant organs, and it is the main cause for cancer-related …

Cell growth inhibition and induction of apoptosis by snake venom toxin in ovarian cancer cell via inactivation of nuclear factor κB and signal transducer and activator …

JK Song, MR Jo, MH Park, HS Song, BJ An… - Archives of pharmacal …, 2012 - Springer
Snake venom toxin from Vipera lebetina turanica induces apoptosis in many cancer cell
lines, but there is no study about the apoptotic effect of snake venom toxin on human ovarian …