The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed
cytoplasmic myosin that participates in a variety of processes requiring the generation of …

Myosins are among the most fascinating enzymes in biology. As extremely allosteric
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …

The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the
expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) …

A common feature of cancer cells is the alteration of kinases and biochemical signalling
pathways enabling transformed growth on soft matrices, whereas cytoskeletal protein …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …

The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction.
We sought to test the mechanisms regulating actin and myosin filament assembly during …

Cell lines are important tools for biological and preclinical investigation, and establishing
their relationship to genomic alterations in tumors could accelerate functional and …

Invasive lobular carcinoma (ILC) is the second most common breast cancer subtype and
accounts for 8–14% of all cases. Although the majority of human ILCs are characterized by …

The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are
inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma …

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical
changes in the cancer cell and its microenvironment. Cells with metastatic potential are often …