The tumor microenvironment (TME), controlled by intrinsic mechanisms of carcinogenesis
and epigenetic modifications, has, in recent years, become a heavily researched topic. The …

Abstract N 6-methyladenosine (m 6 A) is the most abundant modification observed in
eukaryotic mRNAs. Following advancements in transcriptome-wide m 6 A mapping and …

Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …

Recent studies have highlighted the biological significance of RNA N 6-methyladenosine (m
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …

The role of epigenetic regulation in immunity is emerging, especially for RNA N6‐
methyladenosine (m6A) modification. However, little is known about the role of m6A in the …

Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …

5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …

Several strategies, including chemotherapy and radiotherapy, have improved therapeutic
outcomes among cancer patients in clinical practice. However, due to their heterogeneity …

Hepatic stellate cells (HSC) are key effector cells in liver fibrosis. Upon stimulation, the
quiescent HSC undergoes complex morphological and functional changes to …

Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes
of cancer death. Recent studies have provided evidence that N 6-methyladenosine (m 6 A) …