Recent advances in targeted therapies in acute myeloid leukemia

RS Bhansali, KW Pratz, C Lai - Journal of Hematology & Oncology, 2023 - Springer
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …

Targeting acute myeloid leukemia with venetoclax; biomarkers for sensitivity and rationale for venetoclax-based combination therapies

MS Griffioen, DC de Leeuw, JJWM Janssen, L Smit - Cancers, 2022 - mdpi.com
Simple Summary Venetoclax has proven to be a promising therapy for newly diagnosed,
relapsed and refractory AML patients ineligible for induction chemotherapy. Current ongoing …

Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

M Stahl, K Menghrajani, A Derkach, A Chan… - Blood …, 2021 - ashpublications.org
Abstract Azacitidine+ venetoclax, decitabine+ venetoclax, and low-dose cytarabine+
venetoclax are now standard treatments for newly diagnosed older or unfit patients with …

Venetoclax and hypomethylating agent combination therapy in newly diagnosed acute myeloid leukemia: Genotype signatures for response and survival among 301 …

N Gangat, O Karrar, M Iftikhar… - American journal of …, 2024 - Wiley Online Library
Venetoclax+ hypomethylating agent (Ven‐HMA) is currently the standard frontline therapy
for older/unfit patients with newly diagnosed acute myeloid leukemia (ND‐AML). Our …

Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia

AH Matthews, AE Perl, SM Luger, AW Loren… - Blood …, 2022 - ashpublications.org
CPX-351 and venetoclax and azacitidine (ven/aza) are both indicated as initial therapy for
acute myeloid leukemia (AML) in older adults. In the absence of prospective randomized …

Venetoclax with Hypomethylating agents in newly diagnosed Acute myeloid leukemia: a systematic review and Meta-analysis of Survival Data from Real-World …

A Ucciero, F Pagnoni, L Scotti, A Pisterna… - Cancers, 2023 - mdpi.com
Simple Summary The association of venetoclax (VEN) with hypomethylating agents (HMAs)
such as azacitidine (AZA) and decitabine (DECI) significantly improved the outcome of …

Venetoclax with azacitidine or decitabine in blast‐phase myeloproliferative neoplasm: a multicenter series of 32 consecutive cases

N Gangat, P Guglielmelli, N Szuber… - American journal of …, 2021 - Wiley Online Library
Venetoclax (Ven) combined with a hypomethylating agent (HMA) has now emerged as an
effective treatment regimen for acute myeloid leukemia, in both de novo and …

AVALON: The Italian cohort study on real‐life efficacy of hypomethylating agents plus venetoclax in newly diagnosed or relapsed/refractory patients with acute myeloid …

E Todisco, C Papayannidis, N Fracchiolla, E Petracci… - Cancer, 2023 - Wiley Online Library
Background Venetoclax in combination with hypomethylating agents (HMA) is
revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large …

Treatment of myeloid malignancies relapsing after allogeneic hematopoietic stem cell transplantation with venetoclax and hypomethylating agents—a retrospective …

E Schuler, EM Wagner-Drouet, S Ajib, G Bug… - Annals of …, 2021 - Springer
Abstract Treatment of relapse after allogeneic hematopoietic stem cell transplantation
(alloHSCT) remains a great challenge. Aiming to evaluate the combination of venetoclax …

Azacitidine plus venetoclax for the treatment of relapsed and newly diagnosed acute myeloid leukemia patients

S Garciaz, MA Hospital, AS Alary, C Saillard, Y Hicheri… - Cancers, 2022 - mdpi.com
Simple Summary The combination of venetoclax and azacititine (VEN–AZA) has recently
been approved for the treatment of unfit newly diagnosed (ND) acute myeloid leukemia …