Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

Abstract Background Long non-coding RNAs (lncRNAs) are important epigenetic regulators,
which play critical roles in diverse physiological and pathological processes. However, the …

Background Recent studies have revealed that circular RNAs (circRNAs) play significant
roles in the occurrence and development of many kinds of cancers including breast cancer …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Splicing of pre-mRNAs critically contributes to gene regulation and proteome expansion in
eukaryotes, but our understanding of the recognition and pairing of splice sites during …

Lead (Pb) exposure has been a major public health concern for a long time now due to its
permanent adverse effects on the human body. The process of lead toxicity has still not been …

Distant metastasis is, unfortunately, the leading cause of death in colorectal cancer (CRC).
Approximately 50% of CRC patients develop liver metastases, while 10–30% of patients …

The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay
of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 …

With devastating health and socioeconomic impact worldwide, much work is left to
understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely …