The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth
and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a …

Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog
(Shh) protein, which plays a critical role in establishing distinct fates along the anterior …