[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

SS Karnik, KD Singh, K Tirupula… - British journal of …, 2017 - Wiley Online Library
Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

[HTML][HTML] RAAS, ACE2 and COVID-19; a mechanistic review

A Elshafei, EG Khidr, AA El-Husseiny… - Saudi journal of biological …, 2021 - Elsevier
The use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor
blockers (ARBs) in coronavirus disease 2019 (COVID-19) patients has been claimed as …

The RAAS goodfellas in cardiovascular system

I Caputo, G Bertoldi, G Driussi, M Cacciapuoti… - Journal of Clinical …, 2023 - mdpi.com
In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has
revealed a counterregulatory protective axis. This protective arm is characterized by …

Angiotensin-[1–7] attenuates kidney injury in experimental Alport syndrome

HS Choi, IJ Kim, CS Kim, SK Ma, JW Scholey… - Scientific Reports, 2020 - nature.com
Abstract Angiotensin-[1–7](Ang-[1–7]) antagonize the actions of the renin-angiotensin-
system via the Mas receptor and thereby exert renoprotective effects. Murine recombinant …

Transgenic angiotensin-converting enzyme 2 overexpression in the rat vasculature protects kidneys from ageing-induced injury

AM Sanad, F Qadri, E Popova, AF Rodrigues… - Kidney International, 2023 - Elsevier
Chronic kidney disease is one of the leading causes of morbidity and mortality especially
among the aged population. A decline in kidney function with ageing comparable to ageing …

Angiotensin-(1-7)—a potential remedy for AKI: insights derived from the COVID-19 pandemic

SN Heyman, T Walther, Z Abassi - Journal of Clinical Medicine, 2021 - mdpi.com
Membrane-bound angiotensin converting enzyme (ACE) 2 serves as a receptor for the Sars-
CoV-2 spike protein, permitting viral attachment to target host cells. The COVID-19 …

A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic …

P Balakumar, R Sambathkumar, N Mahadevan… - Pharmacological …, 2019 - Elsevier
Epithelial-to-mesenchymal transition (EMT) is an orchestrated event where epithelial cells
progressively undergo biochemical changes and transition into mesenchymal-like cells by …

Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease

M Lin, P Gao, T Zhao, L He, M Li, Y Li, H Shui… - Molecular biology …, 2016 - Springer
To investigate the effects of calcitriol on angiotensin-converting enzyme (ACE) and ACE2 in
diabetic nephropathy. Streptozotocin (STZ) induced diabetic rats were treated with calcitriol …

Angiotensin 1–7 mitigates rhabdomyolysis induced renal injury in rats via modulation of TLR-4/NF-kB/iNOS and Nrf-2/heme‑oxygenase-1 signaling pathways

EA Abdel-Hakeem, SMNA Hafez, BA Kamel… - Life Sciences, 2022 - Elsevier
Aims Rhabdomyolysis (RM) is a critical condition with a high mortality rate, but effective
management is still deficient. Till date, there are no studies that have addressed the effect of …