Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

Pancreatic cancer continues to pose an enormous challenge to clinicians and cancer
scientists. With a more affluent world the global incidence of pancreatic cancer is rising. For …

Transforming growth factor β (TGF-β) superfamily ligands have important roles in regulating
cellular homeostasis, embryonic development, differentiation, proliferation, immune …

Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is
a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell …

Pancreatic islet β-cell dysfunction is a signature feature of Type 2 diabetes pathogenesis.
Consequently, knowledge of signals that regulate β-cell function is of immense clinical …

Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. It
arises from modulation of multiple genes by mutations, epigenetic regulation, noncoding …

In the present study, we aimed to investigate the protective effect of ferulic acid at different
doses (50 mg/kg alternative day and 50 mg/kg daily) on diabetic rats and to explore the …

Pancreatic cancer is the 4th leading cause of cancer-related death in the United States. The
number of diagnoses per year equals the number of deaths per year, making it the deadliest …

Epithelial to mesenchymal transitions (EMTs) contribute to increases in cellular motility and
invasiveness during embryonic development and tumorigenesis. The transforming growth …