Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Parasites of the genus Plasmodium have a complex life cycle. They alternate between their
final mosquito host and their intermediate hosts. The parasite can be either extra-or …

BACKGROUND Vaccines that block human-to-mosquito Plasmodium transmission are
needed for malaria eradication, and clinical trials have targeted zygote antigen Pfs25 for …

Fertilization and zygote development are obligate features of the malaria parasite life cycle
and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is …

The sexual stages of malarial parasites are essential for the mosquito transmission of the
disease and therefore are the focus of transmission-blocking drug and vaccine …

The malaria parasite suffers severe population losses as it passes through its mosquito
vector. Contributing factors are the essential but highly constrained developmental …

Transmission blocking vaccines (TBVs) against malaria are intended to induce immunity
against the stages of the parasites which infect mosquitoes so that TBV-immunised …

The ookinete surface proteins (P25 and P28) are proven antimalarial transmission‐blocking
vaccine targets, yet their biological functions are unknown. By using single (Sko) and double …

Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito,
when they are ingested in an infectious blood meal. Here, we determine the transmission …

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that interrupt
malaria parasite development in the mosquito, thereby blocking onward transmission, and …