A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Microbial production of ectoine and hydroxyectoine as high-value chemicals

M Liu, H Liu, M Shi, M Jiang, L Li, Y Zheng - Microbial Cell Factories, 2021 - Springer
Ectoine and hydroxyectoine as typical representatives of compatible solutes are not only
essential for extremophiles to survive in extreme environments, but also widely used in …

Metabolic engineering for the production of dicarboxylic acids and diamines

TU Chae, JH Ahn, YS Ko, JW Kim, JA Lee, EH Lee… - Metabolic …, 2020 - Elsevier
Microbial production of chemicals and materials from renewable carbon sources is
becoming increasingly important to help establish sustainable chemical industry. In this …

Systems metabolic engineering of Corynebacterium glutamicum for the efficient production of β-alanine

MR Ghiffary, CPS Prabowo, JJ Adidjaja, SY Lee… - Metabolic …, 2022 - Elsevier
Abstract β-Alanine is an important β-amino acid with a growing demand in a wide range of
applications in chemical and food industries. However, current industrial production of β …

Synthetic and therapeutic applications of ammonia-lyases and aminomutases

F Parmeggiani, NJ Weise, ST Ahmed… - Chemical …, 2018 - ACS Publications
Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes
which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or …

Metabolic engineering of microbial cell factories for production of nutraceuticals

SF Yuan, HS Alper - Microbial cell factories, 2019 - Springer
Metabolic engineering allows for the rewiring of basic metabolism to overproduce both
native and non-native metabolites. Among these biomolecules, nutraceuticals have received …

Current status on metabolic engineering for the production of l-aspartate family amino acids and derivatives

Y Li, H Wei, T Wang, Q Xu, C Zhang, X Fan, Q Ma… - Bioresource …, 2017 - Elsevier
The l-aspartate amino acids (AFAAs) are constituted of l-aspartate, l-lysine, l-methionine, l-
threonine and l-isoleucine. Except for l-aspartate, AFAAs are essential amino acids that …

A genome-wide approach for identification and characterisation of metabolite-inducible systems

EKR Hanko, AC Paiva, M Jonczyk, M Abbott… - Nature …, 2020 - nature.com
Inducible gene expression systems are vital tools for the advancement of synthetic biology.
Their application as genetically encoded biosensors has the potential to contribute to …

Highly efficient production of L-homoserine in Escherichia coli by engineering a redox balance route

Q Mu, S Zhang, X Mao, Y Tao, B Yu - Metabolic Engineering, 2021 - Elsevier
L-Homoserine is a nonessential chiral amino acid and the precursor of L-threonine and L-
methionine. It has great potential to be used in the pharmaceutical, agricultural, cosmetic …

Current advancements in the bio-based production of polyamides

JA Lee, JY Kim, JH Ahn, YJ Ahn, SY Lee - Trends in Chemistry, 2023 - cell.com
Polyamides, also known as nylons, are important industrial polymers with repeating amide
bonds. With the growing concern about climate change, technologies that can establish the …