Tuberculous granuloma: emerging insights from proteomics and metabolomics

AR Sholeye, AA Williams, DT Loots… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each
year, is typically characterized by the formation of tuberculous granulomas—the …

Nitrogen metabolism in mycobacteria: the key genes and targeted antimicrobials

Y Xu, S Ma, Z Huang, L Wang, SHA Raza… - Frontiers in …, 2023 - frontiersin.org
Nitrogen metabolism is an important physiological process that affects the survival and
virulence of Mycobacterium tuberculosis. M. tuberculosis's utilization of nitrogen in the …

The Mycobacterium tuberculosis protein O-phosphorylation landscape

A Frando, V Boradia, M Gritsenko, C Beltejar… - Nature …, 2023 - nature.com
Bacterial phosphosignalling has been synonymous with two-component systems and their
histidine kinases, but many bacteria, including Mycobacterium tuberculosis (Mtb), also code …

From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis

LI Rankine-Wilson, T Shapira, C Sao Emani… - …, 2021 - microbiologyresearch.org
Mycobacterium tuberculosis (Mtb) is an obligate human pathogen killing millions of people
annually. Treatment for tuberculosis is lengthy and complicated, involving multiple drugs …

Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG)

RM Qasaymeh, D Rotondo, CB Oosthuizen, N Lall… - Plants, 2019 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a growing public health
concern worldwide, especially with the emerging challenge of drug resistance to the current …

Phosphorylation of plant virus proteins: Analysis methods and biological functions

X Zhuang, X Guo, T Gu, X Xu, L Qin, K Xu… - Frontiers in …, 2022 - frontiersin.org
Phosphorylation is one of the most extensively investigated post-translational modifications
that orchestrate a variety of cellular signal transduction processes. The phosphorylation of …

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases

M Bellinzoni, AM Wehenkel, R Durán, PM Alzari - Genes & Immunity, 2019 - nature.com
Protein phosphorylation is known to be one of the keystones of signal sensing and
transduction in all living organisms. Once thought to be essentially confined to the eukaryotic …

First report on the physicochemical and proteomic characterization of Proteus mirabilis outer membrane vesicles under urine-mimicking growth conditions: comparative analysis …

MJ González, N Navarro, E Cruz, S Sánchez… - Frontiers in …, 2024 - frontiersin.org
Introduction Uropathogenic bacteria employ multiple strategies to colonize the urinary tract,
including biofilm formation, invasion of urothelial cells, and the production of adhesins …

Phosphoproteomic approaches to discover novel substrates of mycobacterial Ser/Thr protein kinases

SS Baros, JM Blackburn, NC Soares - Molecular & Cellular Proteomics, 2020 - ASBMB
Mycobacterial Ser/Thr protein kinases (STPKs) play a critical role in signal transduction
pathways that ultimately determine mycobacterial growth and metabolic adaptation …

Nodulation in the absence of nod genes induction: alternative mechanisms involved in the symbiotic interaction between Cupriavidus sp. UYMMa02A and Mimosa …

C Rodríguez-Esperón, L Sandes, I Eastman… - Environmental …, 2023 - Springer
Cupriavidus sp. UYMMa02A is a beta-rhizobia strain of the Cupriavidus genus, isolated from
nodules of Mimosa magentea in Uruguay. This strain can form effective nodules with several …