Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

CRA Batista, GF Gomes, E Candelario-Jalil… - International journal of …, 2019 - mdpi.com
A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Amyotrophic lateral sclerosis

MA Van Es, O Hardiman, A Chio, A Al-Chalabi… - The Lancet, 2017 - thelancet.com
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes

J Humphrey, S Venkatesh, R Hasan, JT Herb… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …

SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity

M Berdyński, P Miszta, K Safranow, PM Andersen… - Scientific Reports, 2022 - nature.com
Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral
sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower …

[HTML][HTML] A comprehensive review of amyotrophic lateral sclerosis

S Zarei, K Carr, L Reiley, K Diaz, O Guerra… - Surgical neurology …, 2015 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

ALS genes in the genomic era and their implications for FTD

HP Nguyen, C Van Broeckhoven, J van der Zee - Trends in Genetics, 2018 - cell.com
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease, characterized
genetically by a disproportionately large contribution of rare genetic variation. Driven by …

Amyotrophic lateral sclerosis: moving towards a new classification system

A Al-Chalabi, O Hardiman, MC Kiernan, A Chiò… - The Lancet …, 2016 - thelancet.com
Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions …

Regulated cell death: discovery, features and implications for neurodegenerative diseases

J Cui, S Zhao, Y Li, D Zhang, B Wang, J Xie… - Cell Communication and …, 2021 - Springer
Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for
tissue homeostasis or to restore biological balance under stress. Over the decades, various …

The epidemiology of ALS: a conspiracy of genes, environment and time

A Al-Chalabi, O Hardiman - Nature Reviews Neurology, 2013 - nature.com
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …

Estimated prevalence and incidence of amyotrophic lateral sclerosis and SOD1 and C9orf72 genetic variants

CA Brown, C Lally, V Kupelian, WD Flanders - Neuroepidemiology, 2021 - karger.com
Introduction: Amyotrophic lateral sclerosis (ALS) is a rare neurological disorder
characterized by progressive deterioration of motor neurons. Assessment of the …